Twisting and Stretching
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1FROM MOLECULES TO CELLS - IMAGING SOFT SAMPLES WITH THE ATOMIC FORCE MICROSCOPE
M. Radmacher, RW. Tillmann, M. Fritz, HE. Gaub, (gaub@lmu.de )
Science (1992-09-25) 257-5078 p.1900 Science publications
Publisher : AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA. ISSN : 0036-8075
Abstract : Since its invention a few years ago, the atomic force microscope has become one of the most widely used near-field microscopes. Surfaces of hard samples are imaged routinely with atomic resolution. Soft samples, however, remain challenging. An overview is presented on the application of atomic force microscopy to organic samples ranging from thin ordered films at molecular resolution to living cells. Fundamental mechanisms of the image formation are discussed, and novel imaging modes are introduced that exploit different aspects of the tip-sample interaction for local measurements of the micromechanical properties of the sample. As examples, images of Langmuir-Blodgett films, which map the local viscoelasticity as well as the friction coefficient, are presented.
Corresponding Author :
Affiliation(s) : (0) TECH UNIV MUNICH,DEPT PHYS,W-8046 GARCHING,GERMANY.;
Key words : LANGMUIR-BLODGETT-FILMS; SCANNING TUNNELING MICROSCOPY; RESOLUTION IMAGES; HYDRATION FORCES; MONOLAYERS; SURFACES; PROTEIN; WATER
Type : Article, English. 1992-09-25
Time cited 459; Journal impact factor for year 1994 equals 22.067
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