Twisting and Stretching
Single Molecules
Adding a twist to DNA
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1Geometric control of cell life and death
CS. Chen, M. Mrksich, S. Huang, GM. Whitesides, DE. Ingber, (donald.ingber@childrens.harvard.edu )
Science (1997-05-30) 276-5317 p.1425 Science publications
Publisher : AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA. ISSN : 0036-8075
Abstract : Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension. Cell spreading also was varied while maintaining the total cell-matrix contact area constant by changing the spacing between multiple focal adhesion-sized islands. Cell shape was found to govern whether individual cells grow or die, regardless of the type of matrix protein or antibody to integrin used to mediate adhesion. Local geometric control of cell growth and viability may therefore represent a fundamental mechanism for developmental regulation within the tissue microenvironment.
Corresponding Author :
Affiliation(s) : (0) HARVARD UNIV,SCH MED,CHILDRENS HOSP,DEPT SURG,BOSTON,MA 02115.;
(1) HARVARD UNIV,SCH MED,CHILDRENS HOSP,DEPT PATHOL,BOSTON,MA 02115.;
(2) HARVARD UNIV,DEPT CHEM,CAMBRIDGE,MA 02138.;
Key words : SELF-ASSEMBLED MONOLAYERS; FIBROBLAST GROWTH-FACTOR; EXTRACELLULAR-MATRIX; BASEMENT-MEMBRANE; INTEGRIN ALPHA(V)BETA(3); GENE-EXPRESSION; FOCAL ADHESIONS; BLOOD-VESSELS; ANGIOGENESIS; SHAPE
Type : Article, English. 1997-05-30
Time cited 772; Journal impact factor for year 1997 equals 24.676
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